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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > A3 Adenosine Receptor Antibody

A3 Adenosine Receptor Antibody

货号 货期 规格 / 价格 询价
APG01407G  In Stock 50 μl / ¥6950

A3 Adenosine Receptor Antibody

品牌

Leading Biology

货号

APG01407G

产品分类

Polyclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality A3 Adenosine Receptor antibody.

分子量

36185 Da

宿主

Rabbit

种属反应性

Human, Rat

靶点

Peptide (C)KETGAFYGREFKTAK, corresponding to amino acid residues 216-230 of human A3AR (Accession P33765). 3rd intracellular loop.

基因ID

UniProt ID

总结

Adenosine is an endogenous nucleoside generated locally in tissues under conditions of hypoxia, ischemia, or inflammation. It modulates a variety of physiological functions in many tissues including brain and heart.1,2 Adenosine exerts its action via four specific adenosine receptors (also named P1 purinergic receptors): A1-Adenosine receptor (A1AR), A2A-Adenosine receptor (A2AAR), A2B-Adenosine receptor (A2BAR), and A3-Adenosine receptor (A3AR). The various adenosine receptors can be distinguished on the basis of their distinct molecular structures, distinct tissue distributions, and differential selectivity for adenosine analogs.1-4However, all are integral membrane proteins and members of the G Protein-Coupled Receptor superfamily. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, a cytoplasmic carboxyl terminus, and a third intracellular loop that is important for binding G proteins.1-3Expression of A3AR has been reported in brain, kidney, liver, and heart. It plays a role in modulation of cerebral ischemia, asthma, and cell growth. In addition, recent studies have established a cardioprotective role for A3AR.5 Expression of A3AR was reported to be elevated in cancerous tissues as well as in auto-immune inflammatory diseases.6,7 A patent has been filed for the use of A3AR and A3AR agonist as a diagnostic marker for therapeutic treatments of cancer and other diseases. Abgent is pleased to offer a highly specific antibody directed against an intracellular epitope of human A3 Adenosine receptor (A3AR). Anti-A3 Adenosine Receptor antibody (#AG1384) can be used in western blot analysis, as well as immunocytochemical and immunohistocemical applications, and has been designed to recognize A3 Adenosine receptor from human, rat, and mouse samples.

形式

Affinity purified antibody, Liquid

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC, ICC

稀释方法

WB~~1:200-1:2000 IHC~~1:50 ICC~~1:100

别名

Adenosine receptor A3, ADORA3

图像

Western blot analysis of Malme-3M cell lysate: 1. Anti-A3 Adenosine Receptor antibody ( APG01407G), (1:200). 2. Anti-A3 Adenosine Receptor antibody, preincubated with the control peptide antigen.

Expression of A3 Adenosine Receptor in rat lung Immunohistochemical staining of paraffin-embedded rat lung sections using Anti-A3 Adenosine Receptor antibody ( APG01407G), (1:50). Staining is specific for respiratory epithelial cells of the bronchiole (arrows) and pneumonocytes in the alveolar wall (a). Hematoxilin is used as the counterstain.

Expression of A3 Adenosine Receptor in a human melanoma cell line Immunocytochemical staining of paraformaldehyde-fixed and permeabilized human melanoma cells (A2058). A, D. Cells were stained using Anti-A3 Adenosine Receptor antibody ( APG01407G), (1:100), followed by goat anti-rabbit AlexaFluor-555 secondary antibody. B, E. Nuclear fluorescence staining of cells using the membrane-permeable DNA dye Hoechst 33342. C. Merged image of panels A and B. F. Merged image of panels D and E.

说明书

数量

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