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当前位置:首页 > 抗原抗体、ELISA、WB > 一抗 > Polyclonal Antibodies > alpha1A-Adrenoceptor (extracellular) Antibody

alpha1A-Adrenoceptor (extracellular) Antibody

货号 货期 规格 / 价格 询价
APR11384G  In Stock 50 μl / ¥6950

alpha1A-Adrenoceptor (extracellular) Antibody

品牌

Leading Biology

货号

APR11384G

产品分类

Polyclonal Antibodies

研究领域

产品概述

We constantly strive to ensure we provide our customers with the best antibodies. As a result of this work we offer this antibody in purified format. We are in the process of updating our datasheets. If you have any questions regarding this update, please feel free to contact our technical support team. This product is a high quality alpha1A-Adrenoceptor (extracellular) antibody.

分子量

51487 Da

宿主

Rabbit

种属反应性

Human, Rat

靶点

Peptide EDETI*SQINEEPG(C), corresponding to amino acid residues 171-183 of human ?±1A adrenoceptor with replacement of cysteine 176 (C176) with serine (*S)?(Accession ?P35348). 2nd extracellular loop.

基因ID

UniProt ID

总结

Adrenoceptors (also called Adrenergic receptors) are the receptors for the catecholamines adrenaline and noradrenaline (called epinephrine and norepinephrine in the United States). Adrenaline and noradrenaline play important roles in the control of blood pressure, myocardial contractile rate and force, airway reactivity, and a variety of metabolic and central nervous system functions.The Adrenoceptors are members of the G-protein-coupled receptor (GPCR) superfamily of membrane proteins. They share a common structure of seven putative transmembrane domains, an extracellular amino terminus, and a cytoplasmic carboxyl terminus.The Adrenoceptors are divided into three types: α1, α2 and β adrenoceptors. Each type is further divided into at least three subtypes: α1A, α1B, α1D, α2A, α2B, α2C, β1, β2, β3. 1,2They are expressed in nearly all peripheral tissues and in the central nervous system.1,2 All α1-Adrenoceptors (α1-ARs) activate phospholipases C and A2.3In addition to mobilizing intracellular calcium, the α1-ARs have also been shown to activate calcium influx via voltage-dependent and independent calcium channels.4 The α1A-ARs have at least nine known alternative spliced isoforms. They are the most abundant adrenergic receptor in the brain, and considered postsynaptic receptors. α1A-ARs are also expressed in heart, liver and prostate. Abgent is pleased to offer a highly specific antibody directed against an extracellular epitope of the human α1A-Adrenoceptors. Anti-α1A-Adrenoceptor (extracellular) antibody (#AG1381) can be used in western blot analysis and immunohistochemical applications. It has been designed to recognize α1A-Adrenoceptor from human, rat and mouse samples.

形式

Affinity purified antibody, Liquid

储存条件

Store at +4°C short term. For long-term storage, aliquot and store at -20°C or below. Stable for 12 months at -20°C. Avoid repeated freeze-thaw cycles.

应用

WB, IHC

稀释方法

WB~~1:200-1:2000 IHC~~1:100

别名

Alpha-1A adrenergic receptor, Alpha-1A adrenoreceptor, Alpha-1A adrenoceptor, Alpha-1C adrenergic receptor, Alpha-adrenergic receptor 1c, ADRA1A, ADRA1C

图像

Western blot analysis of lysates from K562, PC-3 cell line (from left to right), using ADRA1A Antibody( APR11384G). APR11384G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

Western blot analysis of lysates from human brain tissue and K562 cell line (from left to right), using ADRA1A Antibody( APR11384G). APR11384G was diluted at 1:1000 at each lane. A goat anti-rabbit IgG H&L(HRP) at 1:10000 dilution was used as the secondary antibody. Lysates at 20ug per lane.

Western blot analysis of PC3 cell line lysate (lanes 1 and 3) and rat brain membrane (lanes 2 and 4): 1, 2. Anti-α1A-Adrenoceptor (extracellular) antibody ( APR11384G), (1:200). 3, 4. Anti-α1A-Adrenoceptor (extracellular) antibody, preincubated with the control peptide antigen.

说明书

数量

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